期刊
FEBS LETTERS
卷 580, 期 1, 页码 93-98出版社
WILEY
DOI: 10.1016/j.febslet.2005.11.057
关键词
signal transducer and activator of transcription 3; Kaposi's sarcoma-associated herpesvirus; latency-associated nuclear antigen; transcription
The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) is known to modulate viral and cellular gene expression. We show that LANA directly associates with an interleukin-6 signal transducer, signal transducer and activator of transcription 3 (STAT3) and that LANA enhances the transcriptional activity of STAT3. Coinummoprecipitation studies documented a physical interaction between LANA and STAT3 in transiently transfected 293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line. Furthermore, small-interfering RNA-mediated reduction of LANA expression decreased the STAT3-dependent transcription in KSHV-positive PEL cells, whereas overexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphoma cells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, and may have implications for the pathogenesis of KSHV-associated diseases. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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