期刊
NEUROSCIENCE LETTERS
卷 392, 期 1-2, 页码 114-117出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.09.005
关键词
tackykinin; pain-related behavior; sensitization; spinal cord
Hemokinin-1 (HK-1) is a new peptide described as a member of the tachykinin family. HK-1 has biological effects similar to substance P (SP), a representative of the tachykinin family, following central administration. However, the biological function of HK-1 at the spinal level has not been well characterized. Thus, we investigated the effect of intrathecal administration of HK-1 by comparing it with that of SP. Intrathecal administration of HK-1 as well as SP at 10(-3) M caused pain-related behavior such as scratching. The scratching by HK-1 administration was inhibited by pretreatment with an antagonist of substance P receptor. In addition, Sp (10(-8)-10(-6) M) decreased the latency of the withdrawal response of the hind paw to noxious thermal stimulation 20-30min after intrathecal administration, whereas administration of HK-1 had little effect on this response. These results suggest that there may exist a proper receptor related to HK-1. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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