期刊
TETRAHEDRON
卷 62, 期 2-3, 页码 285-294出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.08.119
关键词
organocatalysis; non-enzymatic asymmetric acylation catalysts; enantioselective acyl transfer; kinetic resolution
The catalytic activity and enantioselectivity of chiral 2,3-dihydroimidazo[1,2-a]pyridine (DHIP) derivatives was examined as a function of the steric environment of the nucleophific nitrogen and the electronic properties of the pyridine ring. 2-Phenyl-6-trifluoroinethyl-DHIP (CF3-PIP) was confirmed to be the best catalyst in this series. In addition, three second-generation catalysts derived from the 1,2dihydroimidazo[1,2-a]quinoline (DHIQ) core were tested and proved to be considerably more active than CF3-PIP. (c) 2005 Elsevier Ltd. All rights reserved.
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