期刊
JOURNAL OF PHYSICS-CONDENSED MATTER
卷 18, 期 1, 页码 L21-L28出版社
IOP PUBLISHING LTD
DOI: 10.1088/0953-8984/18/1/L04
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Mechanically induced protein unfolding in the force-clamp apparatus is shown, in a coarse-grained model of ubiquitin, to have lognormal statistics above a threshold force and exponential statistics below it. Correspondingly, the mean unfolding time is slowly varying and exponentially decreases as a function of the force. The time dependences of the end-to-end distances are also distinct. The time sequence of unfolding events weakly depends on force and much of it resembles that for stretching at constant speed. A more complicated time dependence arises for integrin.
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