期刊
JOURNAL OF NEUROSCIENCE
卷 26, 期 2, 页码 411-417出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3115-05.2006
关键词
aldosterone; ingestive behavior; mineralocorticoid; salt appetite; nucleus of the solitary tract; nucleus tractus solitarius; thirst
资金
- NHLBI NIH HHS [R37 HL025449, HL-25449, R01 HL025449] Funding Source: Medline
Sodium appetite can be enhanced by the adrenal steroid aldosterone via an unknown brain mechanism. A novel group of neurons in the nucleus tractus solitarius expresses the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which makes them selectively responsive to aldosterone. Their activation parallels sodium appetite in different paradigms of salt loss even in the absence of aldosterone. These unique aldosterone target neurons may represent a previously unrecognized central convergence point at which hormonal and neural signals can be integrated to drive sodium appetite.
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