期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 49, 期 1, 页码 31-34出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm051060o
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资金
- Intramural NIH HHS [Z01 AI000693-15] Funding Source: Medline
A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 mu M) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.
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