期刊
IMMUNOLOGY LETTERS
卷 102, 期 1, 页码 106-109出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2005.07.002
关键词
immunoregulatory T cell; suppressive T cell; pregnancy; immunoregulation
类别
Recent evidences indicate that naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells (T-reg) regulate not only autoimmunity, but also alloreactivity. In mice, they notably control tolerance to allogeneic transplants and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Here, we studied the role of T-reg in maternal tolerance to fetuses, i.e. natural semi-allogeneic grafts. We show that semi-allogeneic pregnancies in mice induce an expansion of T-reg, but not of activated CD4(+) and CD8(+) T cells, in para-aortic lymph nodes draining fetal antigens. The treatment of female mice with an anti-CD25 antibody before mating results in depletion of T-reg and expansion of activated CD4(+) and CD8(+) T cells solely in the draining lymph nodes, ultimately leading to fetus rejection. These observations were not made in the context of syngeneic pregnancies. Thus, T-reg play a major role in maternal-fetal tolerance. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据