期刊
ANNALS OF THORACIC SURGERY
卷 88, 期 3, 页码 1036-1043出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2009.02.093
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资金
- United States National Institutes of Health (NIH) [R01GM070628, R01HL085595, K99/R00 HL0876077, 1F32HL092718, F32HL092719]
- American Heart Association [0725663Z]
Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application. (Ann Thorac Surg 2009;88:1036-43) (C) 2009 by The Society of Thoracic Surgeons
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