期刊
BRITISH JOURNAL OF CANCER
卷 94, 期 1, 页码 8-12出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602871
关键词
breast cancer; circulating tumour cells; prognosis; tumour marker; therapeutic monitoring
类别
Circulating tumours cells (CTCs) represent an important biologic link in the spread of breast cancer from primary to metastatic disease. CTCs are strong predictors of prognosis in patients with metastatic breast cancer. Research to date has focused on development of methods with adequate sensitivity and specificity to reproducibly identify these rare events. Future research will focus on the biologic phenotypes of these cells with goals to understand mechanisms of metastasis, to identify novel therapeutic targets, and to monitor response to therapy.
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