期刊
CELL CYCLE
卷 5, 期 2, 页码 138-141出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.5.2.2340
关键词
prostate; cell lineages; cancer; p63; development; stem cells
类别
Understanding the stages of cell differentiation in the normal prostate epithelium is essential for the identification of the cell type(s) involved in prostatic carcinogenesis. Prostate glands are composed of three types of epithelial cells (i.e., basal, secretory and neuroendocrine) but the hierarchical relations among these cell types have long been controversial. We have recently developed a novel system to define prostate epithelial cell lineages in vivo. We find that, during normal prostate organogenesis, terminally differentiated secretory cells derive from p63-positive basal cells, which thus represent/include prostate stem cells. Future studies will determine if p63-positive basal cells retain stem cells capabilities in the adult prostate epithelium.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据