HClO4-SiO2 catalyzed glycosylation using sugar trichloroacetimidates as glycosyl donors

Silica-supported perchloric acid (HClO4-SiO2) has been used as an efficient promoter,, as a replacement of TMSOTf, in various glycosylation reactions using sugar trichloroacetimidates as glycosyl donors. Operational simplicity, economic considerations, high yield, short reaction time and low toxicity were the key features associated with this protocol. (c) 2005 Elsevier Ltd. All rights reserved.