期刊
CELL CYCLE
卷 5, 期 2, 页码 168-171出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.2.2341
关键词
liver; differentiation; hepatocyte; bilary cell; activin/TGF beta signaling gradient; onecut factors; ductal plate malformations
类别
During liver development, liver progenitors called hepatoblasts differentiate into hepatocytes or biliary cells. Recently, we showed that the segregation between hepatocytes and biliary cells is dependent on a gradient of Activin/TGF beta signaling, and that Activin/ TGF beta signaling is controlled in fetal liver by transcription factors of the Onecut family. Here, we discuss candidate factors possibly involved in the formation of the Activin/TGF beta signaling gradient, how this gradient could integrate into a network of signaling pathways modulating hepatoblast differentiation, and the implications for human liver disease and therapy.
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