期刊
FEBS LETTERS
卷 580, 期 2, 页码 450-454出版社
WILEY
DOI: 10.1016/j.febslet.2005.12.037
关键词
macrophage; lipopolysaccharide; elasticity; adhesion; colloidal force microscopy
Colloidal Force Microscopy was employed to study the viscoelastic and adhesive properties of macrophages upon stimulation with lipopolysaccharide (LPS). Force vs. distance measurements were performed. The adhesion of LPS-stimulated cells (separation force = 37 +/- 3 nN) was almost twice as high as that of resting macrophages (16 +/- 1 nN). Upon retraction pulling of membrane tethers was observed. Tether lengths and forces at which rupture take place did not depend on stimulation. The reduced Young's modulus K, a measure of cytoskeleton elasticity, was three times lower than that of the control. The data show that LPS has profound effects on cytomechanical and adhesion properties of macrophages. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据