期刊
ANALYTICA CHIMICA ACTA
卷 556, 期 2, 页码 400-406出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2005.09.063
关键词
solid-phase microextraction; beta-cyclodextrin; ephedrine; amphetamine
Heptakis (2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) blending with hydroxy-terminated silicone oil (OH-TSO) coated solid-phase microextraction (SPME) fiber (DM-beta-CD/OH-TSO) was first prepared with sol-gel technology and applied to headspace SPME for analysis of ephedrine (EP) and methamphetamine (MA) in human urine by gas chromatography (GC), By exploiting the advantages of the unique cavity-shaped cyclic molecular structure of CD and the superiorities of sot-gel coating technique, the novel fiber showed desirable extraction ability and operational stability. Influence of relevant experimental parameters (extraction time, extraction temperature, basicity. ionic strength, etc.) was systematically investigated. In the optimal conditions the proposed headspace SPME-GC method provided good linearity over four orders of magnitude with limit of detection (LOD) of ng/ml (0.33 ng/ml for EP. 0.60 ng/ml for MA). The recoveries of EP and MA in urine were 98.0% and 98.2%. And the relative standard deviations (R.S.D., n = 6) for EP and MA were 3.9% and 5.0%, respectively. (c) 2005 Elsevier B.V. All rights reserved.
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