期刊
BRAIN RESEARCH
卷 1070, 期 1, 页码 31-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.11.038
关键词
epigenetic; hippocampus; pediatric; posttranslational modification; acetylation; methylation
资金
- NICHD NIH HHS [T32 HD040686, T-32 HD 40686] Funding Source: Medline
- NINDS NIH HHS [R01 NS042648, NS42648, R01 NS042648-04] Funding Source: Medline
Posttranslational modifications (PTMs) of histone proteins may result in altered epigenetic signaling after pediatric traumatic brain injury (TBI). Hippocampal histone H3 acetylation and methylation in immature rats after moderate TBI were measured and decreased only in CA3 at 6 h and 24 h with persistent methylation decreases up to 72 h after injury. Decreased histone H3 acetylation and methylation suggest altered hippocampal CA3 epigenetic signaling during the first hours to days after TBI. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据