期刊
CELL
卷 124, 期 2, 页码 263-266出版社
CELL PRESS
DOI: 10.1016/j.cell.2006.01.007
关键词
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资金
- NCI NIH HHS [CA 94173, CA 100324, P30 CA 13330, R01 CA094173] Funding Source: Medline
Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.
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