4.8 Article

An architectural framework that may lie at the core of the postsynaptic density

期刊

SCIENCE
卷 311, 期 5760, 页码 531-535

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1118995

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  1. NCI NIH HHS [R01 CA081000] Funding Source: Medline
  2. NIGMS NIH HHS [R01 GM075922, R01 GM063919-07, R01 GM063919-08, R01 GM075922-04, R01 GM063919] Funding Source: Medline

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The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytosketetat matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

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