期刊
CANCER LETTERS
卷 232, 期 1, 页码 13-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.07.039
关键词
rare fragile sites; common fragile sites; genomic instability; replication stress
类别
Fragile sites are specific loci that form gaps and constrictions on chromosomes exposed to partial replication stress. Fragile sites are classified as rare or common, depending on their induction and frequency within the population. These loci are known to be involved in chromosomal rearrangements in tumors and are associated with human diseases. Therefore, the understanding of the molecular basis of fragile sites is of high significance. Here we discuss the works performed in recent years that investigated the characteristics of fragile sites which underlie their inherent instability. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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