期刊
MONATSHEFTE FUR CHEMIE
卷 137, 期 2, 页码 243-248出版社
SPRINGER WIEN
DOI: 10.1007/s00706-005-0424-6
关键词
3-(substituted)phenyl and heteroarylindoles; antibacterial activity
A synthesis of 3-(4-methoxycarbonyl-2,6-dinitrophenyl)indole, its 2,6-diamino analog, and 3-(2-amino-4-trifluoromethyl-6-nitrophenyl)indole is described. 4-(Trifluoromethyl)phenyl derivatives exhibit higher antibacterial potency than the former 4-(methoxycarbonyl)phenyl homologs, while 3-(4-trifluoromethyl-2-nitrophenyl)indole was the most active agent in the series, with MIC approximate to 7 mu g/cm(3) against E. coli and S. aureus.
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