期刊
JOURNAL OF PROTEOME RESEARCH
卷 5, 期 2, 页码 316-322出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr050331g
关键词
genomic scale; gene ontology; pseudo-amino acid composition; ISort predictor; GO-PseAA fusion classifier; network biology; yeast
To understand the networks in living cells, it is indispensably important to identify protein-protein interactions on a genomic scale. Unfortunately, it is both time-consuming and expensive to do so solely based on experiments due to the nature of the problem whose complexity is obviously overwhelming, just like the fact that life is complicated. Therefore, developing computational techniques for predicting protein-protein interactions would be of significant value in this regard. By fusing the approach based on the gene ontology and the approach of pseudo-amino acid composition, a predictor called GO-PseAA predictor was established to deal with this problem. As a showcase, prediction was performed on 6323 protein pairs from yeast. To avoid redundancy and homology bias, none of the protein pairs investigated has >= 40% sequence identity with any other. The overall success rate obtained by jackknife cross-validation was 81.6%, indicating the GO-PseAA predictor is very promising for predicting protein-protein interactions from protein sequences, and might become a useful vehicle for studying the network biology in the postgenomic era.
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