期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1762, 期 2, 页码 191-201出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2005.07.002
关键词
MAC; mitochondrial apoptosis-induced channel; apoptosis; patch clamp; Bcl-2; Bax
资金
- NIGMS NIH HHS [GM57249] Funding Source: Medline
Programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other pro-apoptotic factors. Control of the formation of the mitochondrial apoptosis-induced channel, or MAC, is central to the regulation of apoptosis by Bcl-2 family proteins. MAC is detected early in apoptosis by patch clamping the mitochondrial outer membrane. The focus of this review is on the regulation of MAC activity by Bcl-2 family proteins. The role of MAC as the putative cytochrome c release channel during early apoptosis and insights concerning its molecular composition are also discussed. (C) 2005 Elsevier B.V. All rights reserved.
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