期刊
FERTILITY AND STERILITY
卷 85, 期 2, 页码 441-445出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2005.08.035
关键词
Y-chromosome; microdeletions; recurrent pregnancy loss; miscarriages; infertility; male factor infertility; habitual abortions
Objective: To determine the prevalence of Y-chromosome microdeletions in recurrent pregnancy loss (RPL) couples as compared with couples with male factor infertility and fertile couples. Design: Controlled clinical study. Setting: Andrology laboratory and RPL clinic. Patient(s): Seventeen men from RPL couples, 18 men from couples with a live birth and no history of miscarriages, and 10 men from couples with male factor infertility. Intervention(S): Buccal smears for Y-chromosome microdeletion testing. Main Outcome Measure(s): The DNA was tested for microdeletions in the proximal AZFc region by polymerase chain reaction (PCR). Result(S): Fourteen of the 17 men (82%) tested had microdeletions in one or more of the four segments studied. Two of the 10 male factor infertility patients (20%) had microdeletions in 2 different segments. None of the 18 fertile men had any microdeletions in the 4 segments of the proximal AZFc region studied. Conclusion(s): The prevalence of the Y-chromosome microdeletions in the proximal AZFc region was much higher in men from RPL couples than from fertile or infertile couples. Although these patients are from a tertiary referral center that may skew the population and findings, one may consider Y-chromosome microdeletion testing particularly of the AZFc region in the evaluation of RPL couples when all other tests fail to reveal the etiology.
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