期刊
SYNLETT
卷 -, 期 2, 页码 283-287出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-923602
关键词
beta-keto sulfide; Michael addition; alpha,beta-unsaturated carbonyl compound; alpha-oxo ketene-S,S-acetal; thiol equivalent
A series of 2-[bis(alkylthio)methylene]-3-oxo-N-o-tolylbutanamides 1 have been investigated as nonthiolic and odorless thiol equivalents in thia-Michael addition reactions. The cleavage of compounds 1 is initiated by NaOH in EtOH; the in situ generated thiolate anions undergo facile conjugate addition to alpha,beta-unsaturated carbonyl compounds 2 affording the corresponding beta-keto sulfides 3 in very high yields. Meanwhile, 3-oxo-N-o-tolylbutanamide 4, the precursor of compounds 1, can be recovered from the novel thia-Michael addition reactions as a byproduct in good yield.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据