期刊
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
卷 124, 期 2, 页码 130-133出版社
ELSEVIER
DOI: 10.1016/j.ejogrb.2005.07.028
关键词
folate; genetic mutations; Down syndrome
Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21. Folate supplementation around conception therefore has the potential to reduce the frequency of Down syndrome. This finding, in addition to the prevention of neural tube defects, strengthens the recommendation to use folic acid around conception. (c) 2005 Published by Elsevier Ireland Ltd.
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