期刊
JOURNAL OF VIROLOGY
卷 80, 期 4, 页码 2063-2068出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.4.2063-2068.2006
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资金
- NIAID NIH HHS [AI48633, T32 AI007110, AI07110, R01 AI048633] Funding Source: Medline
Only the latency-associated transcript (LAT) of the herpes simplex virus type 1(HSV-1) genome is transcribed during latency, while the lytic genes are suppressed, possibly by LAT antisense mechanisms and/or chromatin modifications. In the present study, latently infected dorsal root ganglia were explanted to assess both relative levels of LAT and histone H3 (K9, K14) acetylation of the LAT locus and ICPO promoter at early times postexplant. We observed that a decrease in both LAT enhancer histone H3 (K9, K14) acetylation and LAT RNA abundance occurs prior to an increase in acetylation, or transcriptional permissiveness, at the ICPO promoter.
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