期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 17, 期 1, 页码 34-42出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2005.12.002
关键词
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For many regulators of bacterial biodegradation pathways, small molecule/effector binding is the signal for triggering transcriptional activation. Thus, regulation results from a cross-talk between chemicals sensed by transcriptional factors and operon expression status. These features can be utilised in the construction of biosensors for a wide range of target compounds as, in principle, any regulatory protein whose activity is modulated by binding to a small molecule can have its effector/inducer profile artificially altered The cognate specificities of a number of regulatory proteins have been modified as an astute approach to developing, among others, bacterial biosensors for environmentally relevant compounds.
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