期刊
BIOSYSTEMS
卷 83, 期 2-3, 页码 178-187出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2005.04.006
关键词
quorum sensing; gene expression network; systems biology; mathematical modeling
Understanding the relationship between the structural organization of intracellular decision networks and the observable phenotypes they control is one of the exigent problems of modern systems biology. Here we perform a systems analysis of a prototypic quorum sensing network whose operation allows bacterial populations to activate certain patterns of gene expression cooperatively. We apply structural perturbations to the model and analyze the resulting changes in the network behavior with the aim to identify the contribution of individual network elements to the functional fitness of the whole network. Specifically, we demonstrate the importance of the dimerization of the transcription factor and the presence of the auxiliary positive feedback loop on the switch-like behavior of the network and the stability of its on and off states under the influence of molecular noise. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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