期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 34, 期 -, 页码 12-16出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0340012
关键词
La; mammalian target of rapamycin (mTOR); mRNA; phosphoinositide 3-kinase (PI3K); protein synthesis; translation
Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is reduced significantly. in mammalian cells, this effect is achieved in part through a co-ordinated inhibition of RP (ribosomal protein) synthesis. More specifically, translation initiation on RP mRNAs is inhibited. Translational regulation of RP synthesis is dependent on cis-elements within the 5'-UTRs (5'-untranslated regions) of the RP mRNAs. In particular, a highly conserved 5'-TOP (5'-terminal oligopyrimidine tract) appears to play a key role in the regulation of RP mRNA translation. This article explores recent developments in our understanding of the mechanism of TOP mRNA regulation, focusing on upstream signalling pathways and trans-acting factors, and highlighting some interesting observations which have come to light following the recent development of cDNA microarray technology coupled with polysome analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据