期刊
NEUROSCIENTIST
卷 12, 期 1, 页码 16-28出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858405282417
关键词
neocortex; dendrites; plasticity; neurotrophins
资金
- NIMH NIH HHS [MH 67121] Funding Source: Medline
- NINDS NIH HHS [NS 42241] Funding Source: Medline
Dendrites are a major determinant of how neurons integrate and process incoming information, and thus, they play a vital role in the functional properties of neural circuits. During the past 30 years, it has become clear that the functional organization of the adult neocortex (and other parts of the brain) is dynamic and can change in response to experimental manipulations that affect cortical activity patterns. A variety of changes in the cortical microcircuit, including changes in synaptic function, neuronal membrane properties, and axonal trajectories, are associated with these functional changes. In this review, the authors discuss changes in the structure of dendrites in the adult neocortex, the sorts of experimental manipulations that induce these changes, and some possible molecular mechanisms that may underlie the changes.
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