期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 83, 期 2, 页码 214-220出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2006.02.001
关键词
diabetes; histamine H-1 receptor; tail suspension test; depressive-like behavior; chlorpheniramine; epinastine; cetirizine
We previously reported that streptozotocin-induced diabetic mice showed depressive-like behavior in the tail suspension test. It is well known that the central histaminergic system regulates many physiological functions including emotional behaviors. In this study, we examined the role of the central histaminergic system in the diabetes-induced depressive-like behavior in the mouse tail suspension test. The histamine contents in the hypothalamus were significantly higher in diabetic mice than in non-diabetic mice. The histamine H, receptor antagonist chlorpheniramine (1-10mg/kg, s.c.) dose-dependently and significantly reduced the duration of immobility in both non-diabetic and diabetic mice. In contrast, the selective histamine H, receptor antagonists epinastitic (0.03-0.3 mu g/mouse, i.c.v.) and cetirizine (0.01-0.1 mu g/mouse, i.c.v.) dose-dependently and significantly suppressed the duration of immobility in diabetic mice, but not in non-diabetic mice. Spontaneous locomotor activity was not affected by histamine H, receptor antagonists in either non-diabetic or diabetic mice. In addition, the number and affinity of histamine H, receptors in the frontal cortex were not affected by diabetes. In conclusion, we suggest that the altered neuronal system mediated by the activation of histamine H, receptors is involved, at least in part, in the depressive-like behavior seen in diabetic mice. (c) 2006 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据