期刊
CURRENT OPINION IN CELL BIOLOGY
卷 18, 期 1, 页码 26-31出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.11.005
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- NIGMS NIH HHS [GM44428] Funding Source: Medline
Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.
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