期刊
JOURNAL OF CUTANEOUS PATHOLOGY
卷 33, 期 -, 页码 10-17出版社
WILEY
DOI: 10.1111/j.0303-6987.2006.00507.x
关键词
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资金
- NCI NIH HHS [P50-CA93683] Funding Source: Medline
CD30+ cutaneous lymphoproliferative disorders include lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL). LyP is associated with development of lymphoma in nearly 20% of patients. Herein is reviewed the clonal relationship of LyP to malignant lymphoma, the concept of a common stem cell for LyP and associated lymphomas, and the role of genetic instability in lymphomagenesis. The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated.
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