期刊
OBESITY
卷 14, 期 -, 页码 20S-24S出版社
NORTH AMER ASSOC STUDY OBESITY
DOI: 10.1038/oby.2006.278
关键词
insulin resistance; free fatty acids; body composition
资金
- NCRR NIH HHS [RR-0585] Funding Source: Medline
- NIDDK NIH HHS [DK40484, DK45343, DK50456] Funding Source: Medline
Objective: To review the evidence for and against the role of visceral adipose tissue as a major contributor to the metabolic complications of obesity through abnormal regulation of lipolysis. Research Methods and Procedures: Data from investigators in the field who have studied visceral adiposity and metabolic health and/or regional and systemic free fatty acid (FFA) release were considered. Results: Although visceral fat mass was positively correlated with adverse health consequences and excess FFA availability, visceral fat was not the source of excess systemic FFA availability. Upper body non-visceral fat contributes the majority of FFAs in lean, obese, diabetic, and non-diabetic humans. Increasing amounts of visceral fat probably result in greater hepatic FFA delivery. Discussion: Systemic, as opposed to hepatic, insulin resistance is unlikely to be caused by high rates of visceral adipose tissue lipolysis.
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