期刊
AUTOIMMUNITY REVIEWS
卷 5, 期 2, 页码 156-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2005.10.002
关键词
common variable immune deficiency; autoimmunity; idiopathic thrombocytopenia purpura; hemolytic anemia
类别
Common variable immune deficiency (CVID) is associated with autoimmune and inflammatory complications in addition to recurrent infections. The most common conditions are idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, sarcoid-like granulomatous disease and gastrointestinal inflammation. IVIG administration reduces the frequency of infections, but does not always prevent autoimmunity or inflammation. TNF antagonists and anti-CD20 immunomodulators have shown some efficacy in CVID in a few patients; further controlled studies are needed to determine the best management of these conditions in the setting of immunodeficiency. (c) 2005 Elsevier B.V. All rights reserved.
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