Design and synthesis of spirocyclics via the Diels-Alder reaction and ring-opening cross-metathesis as key steps

Ring-opening-cross-metathesis (ROCM) reaction has been used to prepare spiro-indane derivatives containing six rings. The Diels-Alder (DA) chemistry of indan-2-spiro(cyclopenta-2,4-diene) I with various dienophiles such as 1,4-benzoquinone and its derivatives gave the corresponding DA products in moderate to good yields. Also, we report an improved procedure for preparation of the spiro-diene I using phase-transfer catalysis (PTC) conditions.