期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 17, 期 1-2, 页码 9-17出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2005.09.010
关键词
TGF-beta; Smad; CDK; cell cycle control; cancer
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 Substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function. Because cancer cells often contain high levels of CDK activity, inhibition of Smad activity by CDK phosphorylation may contribute to tumorigenesis and TGF-P resistance in cancers. (c) 2005 Elsevier Ltd. All rights reserved.
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