期刊
TRENDS IN IMMUNOLOGY
卷 27, 期 2, 页码 102-108出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.12.008
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- Medical Research Council [G117/488] Funding Source: researchfish
- MRC [G117/488] Funding Source: UKRI
- Medical Research Council [G117/488] Funding Source: Medline
Complement is not only part of the innate immune system, but has also been implicated in adaptive immunity. The role of complement and its regulatory proteins in modulating T cell activity has been the focus of several recent studies. These, which have included work on the membrane co-factor protein (MCP or CD46), decay accelerating factor (DAF or CD55) and CD59, indicate that complement regulators can influence the proliferative capacity of T cells and their ability to produce cytokines, influencing the outcome of a T cell response to a given antigen. Here we review these studies, which reveal another important link between the innate and the adaptive immune system.
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