期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 83, 期 2, 页码 461S-465S出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/83.2.461s
关键词
leptin; adiponectin; thiazolidinediones; exercise; obesity; hypertension; stroke; hypercholesterolemia; hypertriglyceridemia; BMI; body mass index; adipose tissue
资金
- NIA NIH HHS [AG024635] Funding Source: Medline
- NIDDK NIH HHS [DK50647] Funding Source: Medline
Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion that adipocytes are simply a storage depot for body energy. Instead, adipocytes are also endocrine organs, with multiple metabolic roles in regulating whole-body physiology. Small adipocytes in lean individuals promote metabolic homeostasis; the enlarged adipocytes of obese individuals recruit macrophages and promote inflammation and the release of a range of factors that predispose toward insulin resistance. Exercise activates the AMP-activated protein kinase (AMPK) in muscle and other tissues, a pathway that increases fat oxidation and glucose transport. Importantly, the adipocyte hormones leptin and adiponectin also activate AMPK; remarkably, the same pathway is activated by certain antidiabetic agents such as thiazolidinediones. Increasingly, our understanding of the adipocyte as an endocrine organ is leading to new insights into obesity and health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据