期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 127, 期 2, 页码 188-202出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2005.09.014
关键词
dementia with Lewy bodies; Parkinson's disease; synucleinopathies; alpha-synuclein; therapy
资金
- Medical Research Council [G0400074] Funding Source: researchfish
- MRC [G0400074] Funding Source: UKRI
- Medical Research Council [G0400074] Funding Source: Medline
We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and related neurodegenerative disorders that are characterised by intraneuronal accumulation of alpha-synuclein aggregates. The review addresses the clinico-neuropathological correlates of synaptic pathology in Lewy body disease, and concentrates on: altered a-synuclein metabolism, mechanisms leading to alpha-synuclein fibril formation (self-polymerisation, alpha-synuclein mutations and post-translational modifications) and how these influence the axonal transport and synaptic network in ageing and disease process. Understanding the mechanisms leading to intraneuronal alpha-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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