The effect of maternal characteristics on endothelial-dependent relaxation of myometrial arteries

Objective: Endothelial dysfunction is central to the pathogenesis of pre-eclampsia (PE). This study aimed to determine if maternal characteristics, such as age, parity, BMI, smoking status and obstetric history, which affect the risk of developing pre-eclampsia, influenced endothelial function in myometrial arteries taken during an uncomplicated pregnancy. Study design: As part of ongoing studies investigating endothelial function in normal and compromised pregnancies, myometrial vessels were isolated from biopsies taken at elective Caesarean section. A cohort of 119 women was identified and information regarding past pregnancy outcomes and medical history was obtained. Wire myography was used to compare endothelial-dependent relaxation in response to bradykinin between different patient groups. Results: Maternal age, parity and a history of miscarriage did not affect endothelial-dependent relaxation of myometrial small arteries. Attenuated endothelial-dependent relaxation was seen in vessels taken from women with elevated BMI and enhanced relaxation was seen in women who had smoked during pregnancy. Vessels isolated from women with a history of past pregnancy complications did not show any significant difference in endothelial-dependant relaxation compared to women with uncomplicated histories. Conclusion: Maternal factors may influence endothelial function in the absence of pregnancy complications. Endothelial-dependent relaxation of myometrial arteries, isolated from multiparous women with an uncomplicated index pregnancy, is comparable between women with and without a history of pregnancy complications. (c) 2005 Elsevier Ireland Ltd. All rights reserved.