期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 384, 期 3, 页码 593-600出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-005-0255-7
关键词
magnetic nanoparticle; iron oxide; surface modification; biomolecule detection; patterned surface
Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
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