期刊
EXPERIMENTAL GERONTOLOGY
卷 41, 期 2, 页码 215-219出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2005.10.006
关键词
sarcopenia; metabolism; aging; nutrition; supplements
资金
- NCRR NIH HHS [M01 RR 00073] Funding Source: Medline
- NIA NIH HHS [P30 AG024832] Funding Source: Medline
- NIGMS NIH HHS [5 R01 GM 57295] Funding Source: Medline
To counteract the debilitating progression of sarcopenia, a protein supplement should provide an energetically efficient anabolic stimulus. We quantified net muscle protein synthesis in healthy elderly individuals (65-79 yrs) following ingestion of an isocaloric intact whey protein supplement (WY; n = 8) or an essential amino acid supplement (EAA; n = 7). Femoral arterio-venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed, constant infusion of L-[ring-H-2(5)]phenylalanine. Net phenylalanine uptake and mixed muscle fractional synthetic rate (FSR) were calculated during the post-absorptive period and for 3.5 h following ingestion of 15 g EAA or 15 g whey. After accounting for the residual increase in the intracellular phenylalanine pool, net post-prandial phenylalanine uptake was 53.4 +/- 9.7 mg phe leg(-1) (EAA) and 21.7 +/- 4.6 mg phe leg(-1) (WY), (P < 0.05). Postabsorptive FSR values were 0.056 +/- 0.004% h(-1) (EAA) and 0.049 +/- 0.006% h(-1) (WY), (P > 0.05). Both supplements stimulated FSR (P < 0.05), but the increase was greatest in the EAA group with values of 0.088 +/- 0.01117% h(-1) (EAA) and 0.066 +/- 0.004% h(-1) (WY), (P < 0.05). While both EAA and WY supplements stimulated muscle protein synthesis, EAAs may provide a more energetically efficient nutritional supplement for elderly individuals. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据