期刊
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
卷 12, 期 1, 页码 37-40出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.rhu.0000200420.67262.04
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- NCRR NIH HHS [M01 RR00052] Funding Source: Medline
- NIAMS NIH HHS [AR 43737] Funding Source: Medline
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease most frequently presenting as photosensitive rash, polyarthritis, or renal disease. It represents the tip of the iceberg of autoimmunity. Positive antinuclear antibody (ANA) occurs in 10% or more of normal young women (but 96% or more of patients with SLE). Localized autoimmune disorders such as autoimmune thyroid disease, juvenile-onset diabetes mellitus, Sjogren syndrome, and others Occur in approximately 10% of the population. Systemic autoimmunity, however, is rarer. Undifferentiated connective tissue disease (UCTD) may occur in as many as 5% of Women, but usually does not progress over time into true SLE. SLE remains one of the most fascinating and enigmatic of the autoimmune diseases and a constant challenge to rheumatologists and other specialists.
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