期刊
AUTOIMMUNITY REVIEWS
卷 5, 期 2, 页码 136-139出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2005.09.008
关键词
immunosenescence; aging; naive T cells; autoimmunity; immune-risk phenotype
类别
Aging of the immune system, or immunosenescence, is characterized by changes in T cell subsets, cellular and molecular level alterations and thymic atrophy, resulting in a decline of T and B cell function. These alterations have been shown to be accompanied by a loss of ability to recognize self' and foreign antigens. Therefore the development of autoimmune responses like production of autoantibodies has been hypothesized to be secondary to thymus involution with a decline of naive T cells and accumulation of clonal T cells with activation due to neoantigens during the aging process. Altered apoptosis and altered T cell homeostasis have been emphasized to promote a chronic inflammatory state and lead to the concept of a immune-risk phenotype. However, it has to be proven which kinds of mechanisms turn the immune system to manifest autoimmune disease and how speculated defects in T cell differentiation and interaction leading to premature aging of the immune system may contribute to the development of autoimmune diseases. (c) 2005 Elsevier B.V. All rights reserved.
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