期刊
HUMAN MOLECULAR GENETICS
卷 15, 期 3, 页码 433-442出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddi458
关键词
-
资金
- Medical Research Council [G0000872] Funding Source: researchfish
- MRC [G0000872] Funding Source: UKRI
- Medical Research Council [G0000872] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Many neurodegenerative diseases are caused by intracellular, aggregate-prone proteins, including polyglutamine-expanded huntingtin in Huntington's disease (HD) and mutant tau in fronto-temporal dementia/tauopathy. Previously, we showed that rapamycin, an autophagy inducer, enhances mutant huntingtin fragment clearance and attenuated toxicity. Here we show much wider applications for this approach. Rapamycin enhances the autophagic clearance of different proteins with long polyglutamines and a polyalanine-expanded protein, and reduces their toxicity. Rapamycin also reduces toxicity in Drosophila expressing wild-type or mutant forms of tau and these effects can be accounted for by reductions in insoluble tau. Thus, our studies suggest that the scope for rapamycin as a potential therapeutic in aggregate diseases may be much broader than HD or even polyglutamine diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据