期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 6, 期 2, 页码 163-176出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955706775475911
关键词
Plasmodium; drug development; redox metabolism; thioredoxin; glutathione; structure; target validation; malaria
Antimalarial drugs are urgently and continuously required. Parasite enzymes involved in antioxidant defence represent interesting target molecules for rational drug development. Here we summarize the currently available data on structural, biochemical, and functional properties of these proteins in an attempt to evaluate and compare their potential as drug targets.
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