期刊
VISION RESEARCH
卷 46, 期 4, 页码 467-474出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2005.05.010
关键词
retina; receptive field; dopamine
Receptive fields of gap junction-coupled axon terminals of B-type horizontal cells of isolated rabbit retinae were measured by recording light responses to slit shaped light stimuli at different eccentricities from the recording site. The D1/D5 agonist SKF-38393 and the membrane permeant second messenger 8-bromo-CAMP caused decreases of space constants by 20% while the D1/D5 antagonist SCH-23390 increased space constants by 25 %. The results of this study indicate that axon terminal receptive fields of the rabbit retina can be modulated by D1/D5 receptor activation based on a CAMP-mediated mechanism. The data also suggest the presence of endogenous dopamine as an agent for axon terminal receptive field size modulation. (c) 2005 Elsevier Ltd. All rights reserved.
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