期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 141, 期 2, 页码 211-215出版社
SPRINGER
DOI: 10.1007/s10517-006-0130-3
关键词
nitric oxide; superoxide radical; oxidative stress; lipopolysaccharide; Plaferon LB
We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxernia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress. Plaferon LB protected mice from the toxic effect of lipopolysaccharide.
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