期刊
TRENDS IN CELL BIOLOGY
卷 16, 期 2, 页码 97-104出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2005.12.002
关键词
-
类别
资金
- MRC [MC_U132670601] Funding Source: UKRI
- Medical Research Council [MC_U132670601] Funding Source: researchfish
- Medical Research Council [MC_U132670601] Funding Source: Medline
The death domain-associated protein (Daxx) was originally cloned as a CD95 (FAS)-interacting protein and modulator of FAS-induced cell death. Daxx accumulates in both the nucleus and the cytoplasm; in the nucleus, Daxx is found associated with the promyelocytic leukaemia (PML) nuclear body and with alpha-thalassemia/mental retardation syndrome protein (ATRX)-positive heterochromatic regions. In the cytoplasm, Daxx has been reported to interact with various proteins involved in cell death regulation. Despite a significant number of studies attempting to determine Daxx function in apoptotic and non-apoptotic cell death, its precise role in this process is only partially understood. Here, we critically review the current understanding of Daxx function and shed new light on this interesting field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据