期刊
M S-MEDECINE SCIENCES
卷 22, 期 2, 页码 153-157出版社
EDP SCIENCES S A
DOI: 10.1051/medsci/2006222153
关键词
-
Human skin is always in contact with the environment and is covered with a characteristic microflora, but it is usually not infected. Although desquamation and secretion of mucus lead to a permanent renewal of these body surfaces and simultaneous elimination of microorganisms adhering to these layers, another reason for this natural resistance might be the existence of a chemical barrier consisting in constitutively and inclucibly produced antimicrobial peptides and proteins (AMPS), which include some beta-defensins, RNase 7, the S100-protein psoriasin and the cathelicidin LL-37. Most of these AMPS can be induced in vitro in epithelial cells by proinflammatory cytolkines or bacteria. In vivo, AMPS are mainly expressed in uppermost and differentiated parts of inflammatory lesions and wounds, but some are also focally expressed in skin in the absence of inflammation, suggesting that apart from inflammatory mediators, also non-inflammatory stimuli of endogenous and/or exogenous origin can stimulate AMP-synthesis. Increased levels of AMPS in psoriatic lesions may explain why psoriasis patients rarely suffer from skin infections. Further, an increased infection rate in atopic dermatitis patients could be the consequence of decreased levels of AMPS in atopic lesions. These observations may indicate on important role of the chemical skin barrier in prevention of skin infection and suggest that artificial stimulation of this system, without inflammation, would be beneficial as << immune stimulus >>.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据